Resolution phase lipid mediators of inflammation: agonists of resolution

Endogenous lipid mediators in the resolution of airway inflammation.

Acute inflammation in the lung is fundamentally important to host defence, but chronic or excessive inflammation leads to several common respiratory diseases, including asthma and acute respiratory distress syndrome. The resolution of inflammation is an active process. In health, events at the onset of acute inflammation establish biosynthetic circuits for specific chemical mediators that later...

Emerging Roles of Eosinophils and Eosinophil-Derived Lipid Mediators in the Resolution of Inflammation

Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programs that enable inflamed tissues to return to homeostasis. The mechanisms by which acute inflammation is resolved are of interest, and research in recent years has uncovered new e...

Lipid mediators of inflammation in neurological injury: shifting the balance toward resolution

Vagus nerve controls resolution and pro-resolving mediators of inflammation

Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression of netrin-1, an axonal guidance molecule that activates resolution, and that vagotomy reduced local pro-resolving mediators, thereby delaying resolution. In netrin-1(+/-) mi...

The Role of Lipids Mediators in Inflammation and Resolution

1Departamento de Cĺınica Médica, Laboratorio de Imunofarmacologia Experimental (LIFE), Instituto de Ciências da Saúde, Universidade Federal do Triangulo Mineiro (UFTM), Rua Vigário Carlos 162, 38025-350 Uberaba, MG, Brazil 2Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14049-903 São Paulo, SP, Brazil 3Pulmonary, Critical Care, Sleep and Allergy Medicine, Univ...